Ephrin receptor



Ephrin receptors (EPH) are components of the cell signaling pathways. They belong to the receptor tyrosine kinases. The extracellular ligand-binding domain (LBD) interacts with ephrin. EPH contains a sterile-α-motif (SAM) domain and a second fibronectin III domain (fn3).

Ephrin A1 receptor
3kka - hEPH A1 SAM+ hEPH A2 SAM – human 2k1l - hEPH A1 transmembrane domain – NMR 1x5a - hEPH A1 fn3 domain – NMR

Ephrin A2 receptor
3hpn, 3c8x - hEPH A2 LBD 2x10, 3fl7 - hEPH A2 ectodomain 2k9y, 3e8n - hEPH A2 transmembrane domain – NMR 1mqb - hEPH A2 kinase domain 3mx0, 1x11 - hEPH A2 ectodomain + ephrin A5 3hei, 3czu - hEPH A2 LBD + ephrin A1 3mbw - hEPH A2 LBD + carbohydrate-recognition domain + ephrin A1

Ephrin A3 receptor
2qo2, 2qob, 2gsf - hEPH A3 kinase domain 2qok, 2qol, 2qon, 2qoo, 2qod, 2qof, 2qoi - hEPH A3 kinase domain (mutant)  3fxx, 3fy2 – hEPH A3 kinase domain + peptide substrate 2qoq, 2qo7, 2qo9, 2qoc - hEPH A3 kinase domain + AMP-PNP 3dzq - hEPH A3 kinase domain + inhibitor

Ephrin A4 receptor
2wo1, 3ckh - hEPH A4 LBD 2wo3 - hEPH A4 LBD + ephrin A2 receptor-binding domain 2wo2, 3gxu - hEPH A4 LBD + ephrin B2 receptor-binding domain

Ephrin A5 receptor
2r2p - hEPH A5 kinase domain 1shx - mEPH A5 – mouse

Ephrin A7 receptor
3nru – hEPH A7 LBD<BR /> 3h8m – hEPH A7 SAM<BR /> 2rei - hEPH A7 kinase domain<BR /> 3dko – hEPH A7 kinase domain + inhibitor

Ephrin A8 receptor
3kul - hEPH A8 kinase domain<BR /> 1x5l – hEPH A8 fn3 domain – NMR<BR /> 1ucv - hEPH A8 SAM – NMR<BR />

Ephrin B1 receptor
2eao – hEPH B1 SAM – NMR<BR /> 2djs - hEPH B1 fn3 domain – NMR<BR />

Ephrin B2 receptor
3etp – hEPH B2<BR /> 1f0m – mEPH B2 SAM<BR /> 1sgg - mEPH B2 SAM – chicken - NMR<BR /> 2vsk, 2vsm – hEPH B2 + Viral Hemagglutinin-neuraminidase<BR /> 2qbx – hEPH B2 + peptide agonist<BR /> 2hen - hEPH B2 kinase domain + ADP<BR /> 1shw - mEPH B2 LBD + ephrin A5<BR /> 1kgy - mEPH B2 LBD + ephrin B2 extracellular domain<BR /> 1iko - mEPH B2 ectodomain

Ephrin B3 receptor
3p1i – hEPH B3 LBD<BR />

Ephrin B4 receptor
2qkq – hEPH B4 SAM<BR /> 2e7h – hEPH B4 fn3 domain - NMR<BR /> 2x9f - hEPH B4 kinase domain (mutant) <BR /> 2vwx, 2vwz, 2vx0, 2vx1, 2vwu, 2vwv, 2vww – hEPH B4 + inhibitor <BR /> 2hle, 2bba - hEPH B4 LBD + ephrin B2